Inhibitory Smads and TGF-β Signaling in Glomerular Cells
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چکیده
منابع مشابه
Inhibitory Smads and TGF- Signaling in Glomerular Cells
Smad6 and Smad7 are inhibitory SMADs with putative functional roles at the intersection of major intracellular signaling networks, including TGF, receptor tyrosine kinase (RTK), JAK/STAT, and NFB pathways. This study reports differential functional roles and regulation of Smad6 and Smad7 in TGFsignaling in renal cells, in murine models of renal disease and in human glomerular diseases. Smad7 is...
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The TGF-β family comprises many structurally related differentiation factors that act through a heteromeric receptor complex at the cell surface and an intracellular signal transducing Smad complex. The receptor complex consists of two type II and two type I transmembrane serine/threonine kinases. Upon phosphorylation by the receptors, Smad complexes translocate into the nucleus, where they coo...
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TGF-β/BMP (bone morphogenetic protein) signaling pathways play conserved roles in controlling embryonic development, tissue homeostasis, and stem cell regulation. Inhibitory Smads (I-Smads) have been shown to negatively regulate TGF-β/BMP signaling by primarily targeting the type I receptors for ubiquitination and turnover. However, little is known about how I-Smads access the membrane to execu...
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Programs in Cell Biology and Developmental Biology ence with Smad signaling inhibits the ligand-induced response, Smads are considered as effectors for the ligand-induced transcriptional responses. Recent progress provides insight into the mechanisms through which Smads regulate transcription and explains the sequence heterogeneity of the TGF-/activin-respon-Smads are a class of proteins that ...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2002
ISSN: 1046-6673,1533-3450
DOI: 10.1097/01.asn.0000033276.06451.50